PITCHing ursodeoxycholic acid in intrahepatic cholestasis of pregnancy versus placebo
نویسندگان
چکیده
منابع مشابه
Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid.
Intrahepatic cholestasis of pregnancy (ICP) is a disease characterized by generalized pruritus and biochemical cholestasis that appears typically during the last trimester of gestation. The most predictive and accurate markers for diagnosis and follow-up of ICP are increased total bile acid levels (above 11,0 micromol/L), enhanced cholic acid percentage (above 42%) and decreased glycine/taurine...
متن کاملEfficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy.
UNLABELLED Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. MATERIAL AND METHOD...
متن کاملUrsodeoxycholic acid versus placebo, and early term delivery versus expectantmanagement, in womenwith intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial OPEN ACCESS
Objectives To test whether ursodeoxycholic acid reduces pruritus in women with intrahepatic cholestasis of pregnancy, whether early term delivery does not increase the incidence of caesarean section, and the feasibility of recruiting women with intrahepatic cholestasis of pregnancy to trials of these interventions. Design First phase of a semifactorial randomised controlled trial. Setting Nine ...
متن کاملUrsodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial
OBJECTIVES To test whether ursodeoxycholic acid reduces pruritus in women with intrahepatic cholestasis of pregnancy, whether early term delivery does not increase the incidence of caesarean section, and the feasibility of recruiting women with intrahepatic cholestasis of pregnancy to trials of these interventions. DESIGN First phase of a semifactorial randomised controlled trial. SETTING N...
متن کاملursodeoxycholic acid and s-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy: a meta-analysis
conclusions udca decreased the pruritus score, tba, and alt levels more effectively than same, reducing the rate of preterm delivery for icp. evidence acquisition a meta-analysis of all randomized controlled trials (rcts) comparing udca, same, and combination therapy was performed. we carried out a literature search using pubmed, embase, the cochrane register of controlled trials, and the scien...
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ژورنال
عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology
سال: 2019
ISSN: 1759-5045,1759-5053
DOI: 10.1038/s41575-019-0201-3